How Does Ketamine Work?

Ketamine seems to work differently than traditional mental health medications. Instead of acting on the brain's serotonin or norepinephrine systems, as most antidepressants do, ketamine appears to affect the glutamate system. Glutamate is another chemical messenger in the brain. Researchers think that by affecting this system, ketamine can help to create new connections between brain cells, a process called neuroplasticity. This can help improve mood and alleviate symptoms of mental health disorders.

Ketamine is typically given in a medical setting as an intravenous (IV) infusion or an intramuscular (IM) injection.

Intravenous (IV) Infusion:

This is when ketamine is given through a vein, typically in your arm. A healthcare provider will insert a small needle into your vein and connect it to a tube. The ketamine is then slowly infused into your bloodstream over a period of around 40 minutes to a few hours.

Intramuscular (IM) Injection: 

This is when ketamine is injected directly into a muscle, usually in your upper arm or thigh. The effects tend to come on more quickly than with an IV infusion.

What Can I Expect While Under the Influence of Ketamine ?

It's important to note that the effects of ketamine can be quite intense, and you may experience changes in your perceptions, thoughts, and feelings. Some people describe these experiences as dream-like or psychedelic. Because of these effects, ketamine should always be administered under the supervision of a trained healthcare provider.